Comparative Evaluation on Rutin Content, Radical Scavenging Activity and Properties of Tablets Prepared from Noni Leaf and Fruit Extracts

Abstract

The purpose of this study was to evaluate the rutin content and radical scavenging activity of the leave and fruit extracts of Morinda citrifolia (Noni). The preparation and evaluation of tablets containing the Noni leaf and fruit extracts were also aimed. In this study, the leaves and fruits of Noni were prepared by maceration technique. Their rutin content and antioxidant activity were determined by using High Performance Liquid Chromatography (HPLC) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, respectively. The tablets containing theses extracts were prepared and their physical properties, including thickness and hardness, weight variation and disintegration time (DT) were evaluated. Additionally, the physicochemical stability was evaluated for three months period at 45 ^oC and relative humidity of 75 %. The results showed that Noni leave extract had similar rutin content and antioxidant activity compared to the fruit extract. The physical properties of tablets prepared from these extracts were met the requirements of USP XXX. Following stability test, rutin content and antioxidant activity of the extract and all tablet formulations were decreased.

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